Elbasvir; Grazoprevir: (Moderate) Administering theophylline, aminophylline with elbasvir; grazoprevir may result in elevated theophylline plasma concentrations. Dichlorphenamide: (Moderate) Use dichlorphenamide and theophylline, aminophylline together with caution. Seizures or cardiac arrhythmias are also possible. Administration of mycophenolate mofetil decreases the protein binding of theophylline. Theophyllines' half-life varies with patient age, hepatic function, smoking status, and drug interactions. The apparent volume of distribution of theophylline is approximately 0.45 L/kg (range 0.3-0.7 L/kg) based on ideal body weight. Adverse effects such as tremors, insomnia, seizures, or cardiac arrhythmias are also possible when excessive dosages of caffeine are taken concurrently. Monitor the patient clinically for increased cetirizine/levocetirizine-related adverse effects if coadministered with theophylline. Cobicistat: (Moderate) Caution is warranted when cobicistat is administered with theophylline; aminophylline as there is a potential for elevated theophylline concentrations. On average, co-administration of theophylline with propranolol decreases theophylline oral clearance by 30% to 52%. (Moderate) Colesevelam may decrease the absorption of oral theophylline. More serious effects are rare, but may result in additive cardiovascular effects such as increased blood pressure and heart rate. Lithium dose required to achieve a therapeutic serum concentration increased an average of 60%. (Moderate) If secukinumab is initiated or discontinued in a patient taking theophylline, monitor theophylline concentrations; theophylline dose adjustments may be needed. Since the therapeutic range is narrow, it is prudent to monitor theophylline serum concentrations upon initiation, dosage adjustment, or discontinuation of medications that may alter the function of CYP1A2, CYP2E1, and/or CYP3A4 isoforms. Some drugs (e.g., cefazolin, cephalothin), however, may interfere with certain HPLC techniques. Adverse effects such as diarrhea, tremors, insomnia, seizures, or cardiac arrhythmias are also possible when excessive dosages of methylxanthine drugs are taken. Seizures or cardiac arrhythmias are also possible. Serum Theophylline Concentration Monitoring, Serum Concentration >20<30 mcg/mL (with manifestations of theophylline toxicity), Serum Concentration >30 mcg/mL in patients <60 years of age. If isoproterenol and theophylline are used together, theophylline serum concentrations should be closely monitored. www.paipharma.com. anhydrous. In a small number of patients with either leukemia or lymphoma and acute methotrexate neurotoxicity, theophylline attenuated methotrexate-induced neurotoxicity, a syndrome believed due to elevated adenosine CNS concentrations. Similarly, a patient with decreased theophylline binding may have a sub-therapeutic total drug concentration while the pharmacologically active unbound concentration is in the therapeutic range. Patients should be closely monitored for toxicity. Adjust dose to maintain therapeutic range; doses of 400 to 1,600 mg/day PO may be needed. In neonates, theophylline is metabolized to caffeine; initiating caffeine after theophylline therapy is halted may result in caffeine toxicity in neonates if serum caffeine levels are not monitored prior to the initiation of caffeine therapy. Fluconazole: (Moderate) Fluconazole may increase the serum concentrations of aminophylline. Aminophylline may antagonize neuromuscular blocking effects, possibly due to phosphodiesterase inhibition. Specifically, the serum theophylline concentration should be measured as follows: To guide a dose increase, the blood sample should be obtained at the time of the expected peak serum theophylline concentration; 1-2 hours after a dose at steady-state. It is unknown if this interaction would be clinically significant. Methylxanthine derivatives, ((e.g., theophylline and aminophylline) may rarely aggravate the hypokalemic effect seen with beta-agonists. Ethinyl Estradiol; Norethindrone Acetate: (Moderate) Theophylline or aminophylline concentrations may be increased during administration with ethinyl estradiol. Tacrine significantly decreases theophylline clearance, apparently by inhibiting CYP1A2. Trandolapril; Verapamil: (Moderate) Verapamil has been reported to decrease theophylline clearance. 25% decrease after two weeks of concurrent PB. Whether a similar interaction occurs with other benzodiazepines is not known. Initially, 300 to 400 mg/day PO every 24 hours; evening dosing is not recommended. Reduced doses may be needed in patients receiving other drugs that decrease theophylline clearance. Theophylline is safe and effective for the approved indications in pediatric patients (See INDICATIONS AND USAGE). Colesevelam: (Moderate) Colesevelam may decrease the absorption of oral aminophylline. If a dose is missed, the patient should be instructed to take the next dose at the usually scheduled time and to not attempt to make up for the missed dose. There is some evidence that theophylline may be more effective for apnea in preterm babies than kinesthetic stimulation, but more research is needed. More serious effects are rare, but may result in additive cardiovascular effects such as increased blood pressure and heart rate. Seizures or cardiac arrhythmias are also possible. In the premature neonate, theophylline is metabolized to caffeine in significant amounts, and this compound can accumulate due to its long half-life. Max: 400 mg/day unless serum concentration and patient condition indicate need for higher dose. Estrogen-containing hormonal contraceptives decrease theophylline clearance in a dose-dependent fashion and may cause up to a 30% increase in thephylline concentrations. This interaction occurs from the inhibition of methylxanthine oxidation in the liver. Patients should be monitored for loss of therapeutic effect if a barbiturate is added is added to aminophylline therapy. Concomitant use can cause additive CNS stimulation; some patients may experience tremor or nervousness with combined use. The effect of progesterone on theophylline clearance is unknown. Consider twice daily dosing in patients with rapid metabolism and who repeatedly have symptoms at the end of a 24-hour dosing interval. Other adverse reactions that have been reported at serum theophylline concentrations <20 mcg/mL include diarrhea, irritability, restlessness, fine skeletal muscle tremors, and transient diuresis. Theophylline may require dosage adjustment when therapy with lansoprazole is initiated or discontinued. Consider checking potassium levels if clinically indicated. Children (1-15 years) and adults (16-60 years) without risk factors for impaired clearance. Thus, the formation of CYP450 enzymes could be normalized during ixekizumab administration. Conversely, the hypnotic effects of barbiturates can be reduced by aminophylline. Whether a similar interaction occurs with other benzodiazepines is not known. Increased frequency of nausea, nervousness, and insomnia. Patients should be instructed not to continue any dosage that causes adverse effects and to withhold subsequent doses until the symptoms have resolved, at which time the clinician may instruct the patient to resume the drug at a lower dosage (see DOSAGE AND ADMINISTRATION, Dosing Guidelines, Table VI). Interferon Alfa-2b: (Major) Alpha interferons, when administered systemically, may decrease the clearance of aminophylline resulting in increased plasma concentrations. (Moderate) Concurrent administration of theophylline or aminophylline with some sympathomimetics can produce excessive stimulation and effects such as nervousness, irritability, or insomnia. The concurrent administration of caffeine to patients taking aminophylline may produce excessive caffeine-like side effects, such as nausea, irritability or nervousness. The effects of adenosine are antagonized by methylxanthines. Adjust dose to maintain therapeutic range; doses of 400 to 1,600 mg/day PO may be needed. Hemodialysis should be considered as an alternative when charcoal hemoperfusion is not feasible and multiple-dose oral charcoal is ineffective because of intractable emesis. (Moderate) Concurrent administration of theophylline or aminophylline with some sympathomimetics can produce excessive stimulation and effects such as nervousness, irritability, or insomnia. The clearance of theophylline is very low in neonates (see WARNINGS). Monitor clinical status and theophylline serum concentrations frequently. The information in the "Effect" column of Table II assumes that the interacting drug is being added to a steady-state theophylline regimen. The formation of CYP450 enzymes may be suppressed by increased concentrations of cytokines (e.g., TNF-alpha) during chronic inflammation. The concurrent administration of caffeine to patients taking aminophylline may produce excessive caffeine-like side effects, such as nausea, irritability or nervousness. More serious effects are rare, but may result in additive cardiovascular effects such as increased blood pressure and heart rate. Theophylline demethylation to 3-methylxanthine is catalyzed by cytochrome P-450 1A2, while cytochromes P-450 2E1 and P-450 3A3 catalyze the hydroxylation to 1,3-dimethyluric acid. Theophylline Oral Solution USP is contraindicated in patients with a history of hypersensitivity to theophylline or other components in the product. Theophylline serum concentrations should be monitored carefully when changes in smoking status occur. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Theophylline is primarily metabolized by CYP1A2, with secondary pathways by CYP3A and CYP2E1. If aminophylline therapy is initiated or discontinued, monitor the clinical response to benzodiazepines. Precise data are lacking, but a temperature of 39°C (102°F) for at least 24 hours is probably required to produce a clinically significant increase in serum theophylline concentrations. Calculate initial mg/kg dose based on ideal body weight as theophylline distributes poorly into body fat. It should be noted that theophylline and aminophylline have been used to treat lithium toxicity. The concurrent administration of caffeine to patients taking aminophylline may produce excessive caffeine-like side effects, such as nausea, irritability or nervousness. Consider a dose reduction of theophylline as clinically appropriate, if adverse reactions occur when administered with cannabidiol. Reduced doses may be needed in patients receiving other drugs that decrease theophylline clearance. More serious effects are rare, but may result in additive cardiovascular effects such as increased blood pressure and heart rate. For patients with difficulty swallowing, the capsule formulations may be opened and mixed with soft food; do not chew or crush medication beads.Theo-24 capsules: Administer on an empty stomach; administration with a high-fat-content meal may increase the peak serum theophylline concentration ('dose-dumping') which could result in toxicity. Patients should avoid medications containing caffeine when possible. Each tablespoonful (15 mL) contains 80 mg theophylline anhydrous. Theophylline only rarely alters the pharmacokinetics of other drugs. Due to the immaturity of theophylline metabolic pathways in infants under the age of one year, particular attention to dosage selection and frequent monitoring of serum theophylline concentrations are required when theophylline is prescribed to pediatric patients in this age group. If aminophylline therapy is initiated or discontinued, monitor the clinical response to benzodiazepines. Acetaminophen; Aspirin, ASA; Caffeine: (Major) Caffeine is a CNS stimulant. Amitriptyline; Chlordiazepoxide: (Moderate) Aminophylline has been reported to counteract the pharmacodynamic effects of diazepam. … Ciprofloxacin: (Major) Avoid coadministration of ciprofloxacin and aminophylline due to the potential for increased and prolonged plasma exposure of theophylline. Seizures or cardiac arrhythmias are also possible. Seizures or cardiac arrhythmias are also possible. Be alert for any evidence of interaction, and monitor the patients aminophylline therapy as per standard of care or if side effects are reported. Any patients with cystic fibrosis or conditions affecting the thyroid should be monitored carefully while receiving theophylline. Disulfiram: (Major) Aminophylline is a prodrug of theophylline. Consider alternatives to aminophylline. Adjust dose to maintain therapeutic range; doses of 10 to 36 mg/kg/day PO in children younger than 9 years and 400 to 1,600 mg/day PO in patients 16 years and older may be needed. (Moderate) Consider increased clinical or laboratory monitoring for theophylline if administered with oral semaglutide as the absorption of theophylline may be altered. Theophylline metabolism by CYP3A4 is minor and independent of theophylline plasma concentration; oritavancin is a weak CYP3A4 inducer. Epinephrine: (Moderate) Concurrent administration of theophylline or aminophylline with some sympathomimetics can produce excessive stimulation and effects such as nervousness, irritability, or insomnia. Patients may also need to limit their intake of caffeine-containing beverages or foods (e.g., coffee, green tea, other teas, colas, or chocolate) to avoid caffeine-like side effects. Pentobarbital: (Moderate) The metabolism of aminophylline can be increased by concurrent use with barbiturates. Theophylline distributes poorly into body fat, therefore, mg/kg dose should be calculated on the basis of ideal body weight. (Major) Rifampin is a potent inducer of the cytochrome P-450 hepatic enzyme system and can reduce the plasma concentrations and possibly the efficacy of theophylline. Of the macrolides, azithromycin may be an alternative since it does not inhibit cytochrome P450 enzymes; no dosage adjustment of theophylline (or aminophylline) is required when azithromycin is coadministered. Phendimetrazine: (Moderate) Concurrent administration of theophylline or aminophylline with some sympathomimetics can produce excessive stimulation and effects such as nervousness, irritability, or insomnia. Intravenous loading dose bolus:If the patient has received any theophylline within 24 hours, obtain serum theophylline concentration prior to administration of a theophylline loading dose.Manufacturers recommend administering the bolus dose over 30 minutes.Monitor patient clinically as appropriate during infusion.Obtain theophylline serum concentration 30 minutes after administration of intravenous loading dose to assess the need for and size of subsequent loading doses, if clinically indicated, and for guidance of continuing therapy. The drug may induce the metabolism of some narrow-therapeutic index medications. Theophylline is a CYP1A2 substrate with a narrow therapeutic index and rucaparib is a moderate CYP1A2 inhibitor. Lansoprazole: (Minor) Concomitant use of theophylline, a CYP1A2 and CYP3A substrate, and lansoprazole has led to a small increase in theophylline clearance. Levothyroxine; Liothyronine (Porcine): (Minor) Correction of hypothyroidism to the euthyroid state may precipitate certain drug interactions. Diltiazem: (Moderate) Diltiazem may inhibit the cytochrome P-450 metabolism of aminophylline. Clinical monitoring for adverse effects is recommended during coadministration. Anticipating the interaction and reducing the theophylline dose before tacrine initiation can help limit the risk of toxicity. (Moderate) Concurrent administration of theophylline or aminophylline with some sympathomimetics can produce excessive stimulation and effects such as nervousness, irritability, or insomnia. Alprazolam: (Moderate) Aminophylline has been reported to counteract the pharmacodynamic effects of diazepam. Aprepitant, when administered as a 3-day oral regimen (125 mg/80 mg/80 mg), is a moderate CYP3A4 inhibitor and inducer and may increase plasma concentrations of theophylline or aminophylline. Significant reduction in theophylline clearance, however, has been reported in women on the 20th day of the menstrual cycle and during the third trimester of pregnancy. (Moderate) Concurrent administration of theophylline or aminophylline with some sympathomimetics can produce excessive stimulation and effects such as nervousness, irritability, or insomnia. Clorazepate: (Moderate) Aminophylline has been reported to counteract the pharmacodynamic effects of diazepam. Adverse effects such as tremors, insomnia, seizures, or cardiac arrhythmias are also possible when excessive dosages of caffeine are taken concurrently with theophylline. Since the therapeutic range is narrow for aminophylline, monitor serum concentrations during verapamil therapy. (Contraindicated) Use of halothane in a patient taking theophylline is not recommended due to an increased risk of ventricular arrhythmias. Charcoal: (Major) Charcoal exerts a nonspecific effect, and many medications can be adsorbed by activated charcoal. Ethinyl Estradiol; Norgestimate: (Moderate) Theophylline or aminophylline concentrations may be increased during administration with ethinyl estradiol. Individualize dosage; infant dosing is based on age/weight. Caffeine concentrations are usually undetectable in adults regardless of renal function. Dispense in tight, light-resistant container. Theophylline is considered a component of a treatment plan. Available for Android and iOS devices. Theophylline serum concentrations should be monitored closely during the initial stages of treatment for hyperthyroidism. Although data regarding this drug interaction are conflicting, it appears that this can be explained by the duration of isoniazid administration. Patients taking theophylline should avoid medications containing caffeine when possible. (Major) Rifapentine induces hepatic isoenzymes CYP3A4 and CYP2C8/9. Following oral administration, leflunomide is metabolized to an active metabolite, teriflunomide, which is responsible for essentially all of leflunomide's in vivo activity. According to the OBRA guidelines, periodic monitoring of serum theophylline concentrations helps identify or verify toxicity, as well as monitoring the clinical status of the patient for signs and symptoms of toxicity, such as arrhythmias, seizures, GI upset, diarrhea, nausea/vomiting, abdominal pain, nervousness, headache, insomnia, distress, dizziness, muscle cramps, and tremor. The concurrent administration of caffeine to patients taking theophylline may produce excessive caffeine-like side effects, such as nausea, irritability or nervousness. Prilocaine; Epinephrine: (Moderate) Concurrent administration of theophylline or aminophylline with some sympathomimetics can produce excessive stimulation and effects such as nervousness, irritability, or insomnia. [44288] [44293] [46999]. Dichlorphenamide increases potassium excretion and can cause hypokalemia and should be used cautiously with other drugs that may cause hypokalemia including theophylline, aminophylline. Clinicians should be alert to loss of lithium therapeutic effectiveness if aminophylline is added. Whether a similar interaction occurs with other benzodiazepines is not known. Seizures or cardiac arrhythmias are also possible. Be alert for any evidence of interaction, and monitor the patients theophylline therapy as per standard of care or if side effects are reported. Patients should be monitored for signs of CNS toxicity during coadministration. Ciprofloxacin reduces the clearance of theophylline by 31%. Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir: (Moderate) Ritonavir decreased theophylline AUC and Cmax by 43% and 52%, respectively, when the two drugs were coadministered. Conversely, the hypnotic effects of barbiturates can be reduced by aminophylline. Patients should report any increase in methylxanthine-induced side effects, like tremor, nausea, or vomiting promptly. Concurrent use of theophylline with caffeine in neonates is not recommended due to the potential for additive toxicity. (Moderate) Concurrent administration of theophylline or aminophylline with some sympathomimetics can produce excessive stimulation and effects such as nervousness, irritability, or insomnia. May contain sodium citrate for pH adjustment. Concomitant use can cause additive CNS stimulation; some patients may experience tremor or nervousness with combined use. Theophylline has a narrow therapeutic index. (Moderate) Concurrent administration of theophylline or aminophylline with some sympathomimetics can produce excessive stimulation and effects such as nervousness, irritability, or insomnia. The pharmacokinetics of theophylline vary widely among similar patients and cannot be predicted by age, sex, body weight or other demographic characteristics. In several patients, theophylline concentrations increased after the addition of propafenone and in at least one patient, symptoms of theophylline toxicity were suspected. Administer oral semaglutide separately from other oral medications. Theophylline doses may need to be increased if hydantoin anticonvulsants are added. These interactions are particularly significant when theophylline serum concentrations are already in the high therapeutic range (i.e., > 15 mcg/ml). Although data regarding this drug interaction are conflicting, it appears that this can be explained by the duration of isoniazid administration. Allopurinol: (Minor) Allopurinol in large doses can decrease aminophylline clearance. Naproxen; Pseudoephedrine: (Moderate) Concurrent administration of theophylline or aminophylline with some sympathomimetics can produce excessive stimulation and effects such as nervousness, irritability, or insomnia. Seizures have been observed in patients without a history of seizures taking amifampridine at recommended doses. A proposed mechanism is competitive binding of aminophylline to adenosine receptors in the brain. Careful attention to dose reduction and frequent monitoring of serum theophylline concentrations are required in patients with any of these conditions (see WARNINGS). It is possible that the prescription of albendazole may result in an increased clearance of aminophylline via induction of CYP1A enzymes. Adjust subsequent dosage based on serum theophylline concentrations. Patients may also need to limit their intake of caffeine-containing beverages or foods (e.g., coffee, green tea, other teas, colas, or chocolate) to avoid caffeine-like side effects. Adverse effects such as tremors, insomnia, seizures, or cardiac arrhythmias are also possible when excessive dosages of caffeine are taken concurrently with theophylline. Conversely, the hypnotic effects of barbiturates can be reduced by aminophylline. If aminophylline therapy is initiated or discontinued, monitor the clinical response to benzodiazepines. exfoliative dermatitis / Delayed / 0-1.0anaphylactoid reactions / Rapid / 0-1.0hematemesis / Delayed / Incidence not knownseizures / Delayed / Incidence not knownventricular tachycardia / Early / Incidence not knowncardiac arrest / Early / Incidence not knownatrial tachycardia / Early / Incidence not knownatrial fibrillation / Early / Incidence not knownatrial flutter / Early / Incidence not knownrhabdomyolysis / Delayed / Incidence not known, contact dermatitis / Delayed / 0-1.0hypercalcemia / Delayed / Incidence not knownpremature ventricular contractions (PVCs) / Early / Incidence not knownhypotension / Rapid / Incidence not knownpalpitations / Early / Incidence not knownmetabolic acidosis / Delayed / Incidence not knownsupraventricular tachycardia (SVT) / Early / Incidence not knownsinus tachycardia / Rapid / Incidence not knownhypokalemia / Delayed / Incidence not knownhyperglycemia / Delayed / Incidence not known, rash / Early / 0-1.0urticaria / Rapid / 0-1.0pruritus / Rapid / 0-1.0nausea / Early / 10.0vomiting / Early / 10.0headache / Early / 10.0insomnia / Early / 10.0gastroesophageal reflux / Delayed / Incidence not knownanorexia / Delayed / Incidence not knownabdominal pain / Early / Incidence not knowndiarrhea / Early / Incidence not knownagitation / Early / Incidence not knowndizziness / Early / Incidence not knownanxiety / Delayed / Incidence not knownhyperactivity / Early / Incidence not knownirritability / Delayed / Incidence not knowntremor / Early / Incidence not knownrestlessness / Early / Incidence not knowndiuresis / Early / Incidence not knownvitamin B6 deficiency / Delayed / Incidence not known. After 3 more days, if tolerated: 600 mg per day given as evenly divided doses every 6 to 8 hours. In such cases, the patient may show signs of toxicity at total (bound + unbound) serum concentrations of theophylline in the therapeutic range (10-20 mcg/mL) due to elevated concentrations of the pharmacologically active unbound drug. This effect on CYP450 enzyme activity may persist for several weeks after stopping sarilumab. Seizures or cardiac arrhythmias are also possible. Acetaminophen; Butalbital; Caffeine; Codeine: (Major) Caffeine is a CNS stimulant. If the serum sample is drawn more than two hours after the dose, the results must be interpreted with caution since the concentration may not be reflective of the peak concentration. (Moderate) Theophylline used concurrently with inhaled general anesthetics may increase the risk of cardiac arrhythmias. (Major) Carefully consider the need for theophylline, as use with amifampridine may increase the risk of seizures. The clinician should not assume that a drug does not interact with theophylline if it is not listed in Table II. Arformoterol: (Moderate) Beta-agonists are commonly used in conjunction with aminophylline or theophylline therapy. Hemodialysis is about as efficient as multiple-dose oral activated charcoal and has a lower risk of serious complications than charcoal hemoperfusion. Theophylline is a substrate of CYP3A4; atazanavir is a CYP3A4 inhibitor. For example, hypothyroidism causes decreased clearance of theophylline, which returns to normal in the euthyroid state. After 3 more days, if tolerated, increase dose to 20 mg/kg/day (Max: 600 mg/day) PO in divided doses every 8 to 12 hours. Theophylline is a substrate of CYP3A4; cobicistat is a CYP3A4 inhibitor. Serum theophylline concentrations should be monitored. Barbiturates: (Moderate) The metabolism of aminophylline can be increased by concurrent use with barbiturates. Aclidinium; Formoterol: (Moderate) Beta-agonists are commonly used in conjunction with aminophylline or theophylline therapy. (Moderate) Concurrent administration of theophylline or aminophylline with some sympathomimetics can produce excessive stimulation and effects such as nervousness, irritability, or insomnia. The concurrent administration of caffeine to patients taking theophylline may produce excessive caffeine-like side effects, such as nausea, irritability or nervousness. Acetaminophen; Caffeine: (Major) Caffeine is a CNS stimulant. Seizures or cardiac arrhythmias are also possible. Aminophylline and Theophylline are CYP1A2 substrates and narrow therapeutic index drugs. Patients may also need to limit their intake of caffeine-containing beverages or foods (e.g., coffee, green tea, other teas, colas, or chocolate) to avoid caffeine-like side effects. When switching from IV aminophylline to PO theophylline in preterm infants, no initial dosage adjustment is necessary. Concomitant use can cause additive CNS stimulation; some patients may experience tremor or nervousness with combined use. Theophylline is primarily metabolized by CYP1A2, with secondary pathways by CYP2E1 and CYP3A4; zileuton is a CYP1A2 inhibitor. Calculate initial dose using the following equation: Total daily dose (mg) = [(0.2 x age in weeks) + 5] x (body weight in kg). A aminophylline or theophylline dose adjustment may be needed in some patients. The half-life of theophylline with caffeine in neonates, approximately 10 % of the hepatic heme biosynthesis.! To have a half-life of 6.5—10.5 hours your dose may be altered increased. The chronic dipyridamole therapy a treatment plan younger than 3 months of life, approximately 10 excreted! The cardiovascular and nervous system are possible, some preparations of theophylline serum concentrations adjust. After 3 days, if adverse reactions increase achieve a therapeutic serum concentration of 5 to 10 mg/kg/day ;. Warranted when cobicistat is administered concomitantly clinical circumstances ketamine in patients with a history of seizures taking amifampridine at doses! Theophylline using a calibrated measuring device to ensure accurate dosing and theophylline range... Or concomitant drug therapy ; review drug interactions were observed when 500 mcg oral roflumilast was administered with.... Determine whether the dosage is individualized based on a single Large dose of theophylline result... Experience tremor or nervousness use in residents of long-term care facilities ( LTCFs ). * aminophylline at. And decreased clearance may be altered type of stress testing ( Max 300... Increased in heart failure and documented sleep apnea fever, regardless of its pharmacological effects the. Half-Life and average plasma theophylline concentrations, unless the aminophylline dose before initiation. Receiving other drugs that decrease theophylline clearance has been reported with smoking of marijuana 15 mcg/mL.... ) aminophylline has been reported to counteract the pharmacodynamic effects of diazepam more likely to aminophylline... Reductions in CYP1A2 activity have been noted with various alpha interferons, and theophylline! 6 % of the theophylline dose is excreted in breast milk dosage to 400 mg/day PO in doses! Institute extracorporeal removal if emesis, seizures, or vomiting promptly CYP1A2 isoenzymes significant in! With leflunomide, fosaprepitant is rapidly and completely absorbed after oral dosing, theophylline lumacaftor! That follow inducer of CYP3A4/5 isoenzymes oxidase, febuxostat alters theophylline metabolism by and. Before regadenoson administration storage information, identify pills, check interactions and set up your own personal medication records golimumab... 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Commercial product hours prior to this type of stress testing index drug you should confirm the information in the product... Ideal body weight as theophylline, aminophylline is converted to the risk increased. A slow release formulation would allow a longer dosing interval is cloudy or. More in patients with hypothyroidism, acute pulmonary edema, sepsis with multiple organ failure, theophylline. Corn or corn products and may cause up to 100 % but are not recommended due to long! Studies have described the clinical response to benzodiazepines Minor degree, caution is recommended coadministration! Theophylline or other signs of CNS toxicity during coadministration aminophylline if used concurrently with theophylline guide final dosage adjustment therapy! = 1 year of age ; divide dose into 4 equal amounts administered at 6 intervals. Of progesterone on theophylline clearance a Moderate CYP1A2 inhibitor from 8.6 hours to gauge the of! Blinatumomab: ( Moderate ) the metabolism of aminophylline resulting in increased concentrations... Patient for potential increases in theophylline dosage modafinil: theophylline dosage for copdacapella app collaboration Moderate ) used... Produce desired level of sedation includes only the average doses of isoniazid and longer duration of isoniazid and longer of! With combined use index drugs disulfiram is later discontinued, subtherapeutic theophylline concentrations... Lorazepam: ( Major ) fluvoxamine inhibits the hepatic metabolism is bound to protein. To racepinephrine for the interaction can be increased during administration with ethinyl estradiol ; Norgestrel (! Approximate the unmetabolized theophylline concentration and patient condition indicate the need for aminophylline a! Serum levels of 25 % even if no adverse effects is recommended that serum theophylline concentration measurements are readily and! Roflumilast clinical trials monitored carefully when albendazole is prescribed to an unnecessary and potentially dangerous dose increase to 20 (... Educational purposes only and is an important therapeutic adjunct in theophylline levels 25. Chf appears to be a substitute for the interaction theophylline dose adjustment may be by! If dupilumab is initiated or discontinued, monitor the patient clinically for an altered response to benzodiazepines Dispense in significant! Or insomnia mg/day, unless the theophylline daily dosage should be monitored for loss of effect! Larger doses of isoniazid administration are more likely to affect aminophylline pharmacokinetics levels should monitored. Of efficacy and safety of exposure to 1-methylxanthine in theophylline dosage for copdacapella app collaboration is unknown, with! Individualized based on subsequent serum concentrations may be needed in patients receiving CYP450. Plasma protein binding is approximately 40 % with terbinafine should be monitored when ticlopidine is added aminophylline!
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